Kinetochore assembly: if you build it, they will come

Author(s)
Gascoigne, Karen E; Cheeseman, Iain M
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Abstract
Accurate chromosome segregation requires the interaction of chromosomes with the microtubules from the mitotic spindle. This interaction is mediated by the macro-molecular kinetochore complex, which assembles only at the centromeric region of each chromosome. However, how this site is specified and how assembly of the kinetochore structure is regulated in coordination with cell cycle progression remains unclear. Recent studies have begun to shed light on the mechanisms underlying assembly of this complex structure.
Date issued
2010-08
URI
http://hdl.handle.net/1721.1/98535
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Current Opinion in Cell Biology
Publisher
Elsevier
Citation
Gascoigne, Karen E, and Iain M Cheeseman. “Kinetochore Assembly: If You Build It, They Will Come.” Current Opinion in Cell Biology 23, no. 1 (February 2011): 102–108.
Version: Author's final manuscript
ISSN
09550674
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