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dc.contributor.authorMeyer, Anne S.
dc.contributor.authorBaker, Tania
dc.date.accessioned2015-09-22T19:05:01Z
dc.date.available2015-09-22T19:05:01Z
dc.date.issued2011-02
dc.identifier.issn13695274
dc.identifier.urihttp://hdl.handle.net/1721.1/98874
dc.description.abstractProteolysis is a fundamental process used by all forms of life to maintain homeostasis, as well as to remodel the proteome following environmental changes. Here, we explore recent advances in understanding the role of proteolysis during the heat shock response of Escherichia coli. Proteolysis both regulates and contributes directly to and the heat shock response at multiple different levels, from adjusting the levels of the master heat shock response regulator (σ[superscript 32]), to eliminating damaged cellular proteins, to altering the activity of chaperones that refold heat-denatured proteins. Recent results illustrate the complexity of the heat shock response and the pervasive role that proteolysis plays in both the cellular response to heat shock and the subsequent limiting of the response, as cells return to a more ‘normal’ physiological state.en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.mib.2011.02.001en_US
dc.rightsCreative Commons Attribution-Noncommercial-NoDerivativesen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleProteolysis in the Escherichia coli heat shock response: a player at many levelsen_US
dc.typeArticleen_US
dc.identifier.citationMeyer, Anne S, and Tania A Baker. “Proteolysis in the Escherichia Coli Heat Shock Response: a Player at Many Levels.” Current Opinion in Microbiology 14, no. 2 (April 2011): 194–199.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorMeyer, Anne S.en_US
dc.contributor.mitauthorBaker, Taniaen_US
dc.relation.journalCurrent Opinion in Microbiologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMeyer, Anne S; Baker, Tania Aen_US
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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