Constructing ensembles for intrinsically disordered proteins
Author(s)Stultz, Collin M.; Fisher, Charles K.
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The relatively flat energy landscapes associated with intrinsically disordered proteins makes modeling these systems especially problematic. A comprehensive model for these proteins requires one to build an ensemble consisting of a finite collection of structures, and their corresponding relative stabilities, which adequately capture the range of accessible states of the protein. In this regard, methods that use computational techniques to interpret experimental data in terms of such ensembles are an essential part of the modeling process. In this review, we critically assess the advantages and limitations of current techniques and discuss new methods for the validation of these ensembles.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Research Laboratory of Electronics
Current Opinion in Structural Biology
Fisher, Charles K, and Collin M Stultz. “Constructing Ensembles for Intrinsically Disordered Proteins.” Current Opinion in Structural Biology 21, no. 3 (June 2011): 426–31.
Author's final manuscript