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CD8α[superscript +] Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites

Author(s)
Mashayekhi, Mona; Sandau, Michelle M.; Dunay, Ildiko R.; Frickel, Eva M.; Khan, Asis; Goldszmid, Romina S.; Sher, Alan; Murphy, Theresa L.; Sibley, L. David; Murphy, Kenneth M.; Ploegh, Hidde; ... Show more Show less
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Abstract
CD8α[superscript +] dendritic cells (DCs) are important in vivo for cross-presentation of antigens derived from intracellular pathogens and tumors. Additionally, secretion of interleukin-12 (IL-12) by CD8α[superscript +] DCs suggests a role for these cells in response to Toxoplasma gondii antigens, although it remains unclear whether these cells are required for protection against T. gondii infection. Toward this goal, we examined T. gondii infection of Batf3[superscript −/−] mice, which selectively lack only lymphoid-resident CD8α[superscript +] DCs and related peripheral CD103[superscript +] DCs. Batf3[superscript −/−] mice were extremely susceptible to T. gondii infection, with decreased production of IL-12 and interferon-γ. IL-12 administration restored resistance in Batf3[superscript −/−] mice, and mice in which IL-12 production was ablated only from CD8α[superscript +] DCs failed to control infection. These results reveal that the function of CD8α[superscript +] DCs extends beyond a role in cross-presentation and includes a critical role for activation of innate immunity through IL-12 production during T. gondii infection.
Date issued
2011-08
URI
http://hdl.handle.net/1721.1/99164
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Immunity
Publisher
Elsevier/Cell Press
Citation
Mashayekhi, Mona, Michelle M. Sandau, Ildiko R. Dunay, Eva M. Frickel, Asis Khan, Romina S. Goldszmid, Alan Sher, et al. “CD8α[superscript +] Dendritic Cells Are the Critical Source of Interleukin-12 That Controls Acute Infection by Toxoplasma Gondii Tachyzoites.” Immunity 35, no. 2 (August 2011): 249–259.
Version: Author's final manuscript
ISSN
10747613
1097-4180

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