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dc.contributor.authorArtzi, Natalie
dc.contributor.authorZeiger, Adam
dc.contributor.authorBoehning, Fiete
dc.contributor.authorbon Ramos, Adriana
dc.contributor.authorEdelman, Elazer R.
dc.contributor.authorVan Vliet, Krystyn J.
dc.date.accessioned2015-10-08T13:04:22Z
dc.date.available2015-10-08T13:04:22Z
dc.date.issued2010-07
dc.date.submitted2010-06
dc.identifier.issn17427061
dc.identifier.urihttp://hdl.handle.net/1721.1/99200
dc.description.abstractSoft tissue adhesives are employed to repair and seal many different organs, which range in both tissue surface chemistry and mechanical challenges during organ function. This complexity motivates the development of tunable adhesive materials with high resistance to uniaxial or multiaxial loads dictated by a specific organ environment. Co-polymeric hydrogels comprising aminated star polyethylene glycol and dextran aldehyde (PEG:dextran) are materials exhibiting physico-chemical properties that can be modified to achieve this organ- and tissue-specific adhesion performance. Here we report that resistance to failure under specific loading conditions, as well as tissue response at the adhesive material–tissue interface, can be modulated through regulation of the number and density of adhesive aldehyde groups. We find that atomic force microscopy (AFM) can characterize the material aldehyde density available for tissue interaction, and in this way enable rapid, informed material choice. Further, the correlation between AFM quantification of nanoscale unbinding forces with macroscale measurements of adhesion strength by uniaxial tension or multiaxial burst pressure allows the design of materials with specific cohesion and adhesion strengths. However, failure strength alone does not predict optimal in vivo reactivity. Thus, we demonstrate that the development of adhesive materials is significantly enabled when experiments are integrated along length scales to consider organ chemistry and mechanical loading states concurrently with adhesive material properties and tissue response.en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Career Award)en_US
dc.description.sponsorshipAmerican Society for Engineering Education. National Defense Science and Engineering Graduate Fellowshipen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant ERE GM 49039)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.actbio.2010.07.008en_US
dc.rightsCreative Commons Attribution-Noncommercial-NoDerivativesen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleTuning adhesion failure strength for tissue-specific applicationsen_US
dc.typeArticleen_US
dc.identifier.citationArtzi, Natalie, Adam Zeiger, Fiete Boehning, Adriana bon Ramos, Krystyn Van Vliet, and Elazer R. Edelman. “Tuning Adhesion Failure Strength for Tissue-Specific Applications.” Acta Biomaterialia 7, no. 1 (January 2011): 67–74.en_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.mitauthorArtzi, Natalieen_US
dc.contributor.mitauthorZeiger, Adamen_US
dc.contributor.mitauthorBoehning, Fieteen_US
dc.contributor.mitauthorbon Ramos, Adrianaen_US
dc.contributor.mitauthorVan Vliet, Krystyn J.en_US
dc.contributor.mitauthorEdelman, Elazer R.en_US
dc.relation.journalActa Biomaterialiaen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsArtzi, Natalie; Zeiger, Adam; Boehning, Fiete; bon Ramos, Adriana; Van Vliet, Krystyn; Edelman, Elazer R.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5735-0560
dc.identifier.orcidhttps://orcid.org/0000-0002-7832-7156
mit.licensePUBLISHER_CCen_US


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