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dc.contributor.authorPolz, Martin F.
dc.contributor.authorAlm, Eric J.
dc.contributor.authorHanage, William P.
dc.date.accessioned2015-10-13T12:22:28Z
dc.date.available2015-10-13T12:22:28Z
dc.date.issued2013-01
dc.identifier.issn01689525
dc.identifier.urihttp://hdl.handle.net/1721.1/99217
dc.description.abstractMany bacterial and archaeal lineages have a history of extensive and ongoing horizontal gene transfer and loss, as evidenced by the large differences in genome content even among otherwise closely related isolates. How ecologically cohesive populations might evolve and be maintained under such conditions of rapid gene turnover has remained controversial. Here we synthesize recent literature demonstrating the importance of habitat and niche in structuring horizontal gene transfer. This leads to a model of ecological speciation via gradual genetic isolation triggered by differential habitat-association of nascent populations. Further, we hypothesize that subpopulations can evolve through local gene-exchange networks by tapping into a gene pool that is adaptive towards local, continuously changing organismic interactions and is, to a large degree, responsible for the observed rapid gene turnover. Overall, these insights help to explain how bacteria and archaea form populations that display both ecological cohesion and high genomic diversity.en_US
dc.description.sponsorshipGordon and Betty Moore Foundationen_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant DEB 0821391)en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.) (Grant GM088558-01)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.tig.2012.12.006en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleHorizontal gene transfer and the evolution of bacterial and archaeal population structureen_US
dc.typeArticleen_US
dc.identifier.citationPolz, Martin F., Eric J. Alm, and William P. Hanage. “Horizontal Gene Transfer and the Evolution of Bacterial and Archaeal Population Structure.” Trends in Genetics 29, no. 3 (March 2013): 170–175.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Civil and Environmental Engineeringen_US
dc.contributor.mitauthorPolz, Martin F.en_US
dc.contributor.mitauthorAlm, Eric J.en_US
dc.relation.journalTrends in Geneticsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsPolz, Martin F.; Alm, Eric J.; Hanage, William P.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8294-9364
dc.identifier.orcidhttps://orcid.org/0000-0001-9296-3733
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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