Casting inorganic structures with DNA molds
Author(s)Sun, Wei; Boulais, Etienne; Hakobyan, Yera; Wang, Wei Li; Guan, Amy; Bathe, Mark; Yin, Peng; ... Show more Show less
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We report a general strategy for designing and synthesizing inorganic nanostructures with arbitrarily prescribed three-dimensional shapes. Computationally designed DNA strands self-assemble into a stiff “nanomold” that contains a user-specified three-dimensional cavity and encloses a nucleating gold “seed.” Under mild conditions, this seed grows into a larger cast structure that fills and thus replicates the cavity. We synthesized a variety of nanoparticles with 3-nanometer resolution: three distinct silver cuboids with three independently tunable dimensions, silver and gold nanoparticles with diverse cross sections, and composite structures with homo- and heterogeneous components. The designer equilateral silver triangular and spherical nanoparticles exhibited plasmonic properties consistent with electromagnetism-based simulations. Our framework is generalizable to more complex geometries and diverse inorganic materials, offering a range of applications in biosensing, photonics, and nanoelectronics.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering
American Association for the Advancement of Science (AAAS)
Sun, W., E. Boulais, Y. Hakobyan, W. L. Wang, A. Guan, M. Bathe, and P. Yin. “Casting Inorganic Structures with DNA Molds.” Science 346, no. 6210 (October 9, 2014): 1258361–1258361.
Author's final manuscript