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dc.contributor.authorMoskowitz, Joshua Seth
dc.contributor.authorBlaisse, Michael R.
dc.contributor.authorSamuel, Raymond E.
dc.contributor.authorHsu, Hu-Ping
dc.contributor.authorHarris, Mitchel B.
dc.contributor.authorMartin, Scott
dc.contributor.authorLee, Jean C.
dc.contributor.authorSpector, Myron
dc.contributor.authorHammond, Paula T.
dc.date.accessioned2015-10-21T15:31:10Z
dc.date.available2015-10-21T15:31:10Z
dc.date.issued2010-05
dc.date.submitted2010-02
dc.identifier.issn01429612
dc.identifier.issn1878-5905
dc.identifier.urihttp://hdl.handle.net/1721.1/99390
dc.description.abstractWhile the infection rate of orthopedic implants is low, the required treatment, which can involve six weeks of antibiotic therapy and two additional surgical operations, is life threatening and expensive, and thus motivates the development of a one-stage re-implantation procedure. Polyelectrolyte multilayers incorporating gentamicin were fabricated using the layer-by-layer deposition process for use as a device coating to address an existing bone infection in a direct implant exchange operation. The films eluted about 70% of their payload in vitro during the first three days and subsequently continued to release drug for more than four additional weeks, reaching a total average release of over 550 μg/cm[superscript 2]. The coatings were demonstrated to be bactericidal against Staphylococcus aureus, and degradation products were generally nontoxic towards MC3T3-E1 murine preosteoblasts. Film-coated titanium implants were compared to uncoated implants in an in vivo S. aureus bone infection model. After a direct exchange procedure, the antimicrobial-coated devices yielded bone homogenates with a significantly lower degree of infection than uncoated devices at both day four (p < 0.004) and day seven (p < 0.03). This study has demonstrated that a self-assembled ultrathin film coating is capable of effectively treating an experimental bone infection in vivo and lays the foundation for development of a multi-therapeutic film for optimized, synergistic treatment of pain, infection, and osteomyelitis.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (National Institute on Aging Grant 5R01AG029601-03)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.biomaterials.2010.04.011en_US
dc.rightsCreative Commons Attribution-Noncommercial-NoDerivativesen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleThe effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone modelen_US
dc.typeArticleen_US
dc.identifier.citationMoskowitz, Joshua S., Michael R. Blaisse, Raymond E. Samuel, Hu-Ping Hsu, Mitchel B. Harris, Scott D. Martin, Jean C. Lee, Myron Spector, and Paula T. Hammond. “The Effectiveness of the Controlled Release of Gentamicin from Polyelectrolyte Multilayers in the Treatment of Staphylococcus Aureus Infection in a Rabbit Bone Model.” Biomaterials 31, no. 23 (August 2010): 6019–6030.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.mitauthorMoskowitz, Joshua Sethen_US
dc.contributor.mitauthorBlaisse, Michael R.en_US
dc.contributor.mitauthorSamuel, Raymond E.en_US
dc.contributor.mitauthorHammond, Paula T.en_US
dc.relation.journalBiomaterialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMoskowitz, Joshua S.; Blaisse, Michael R.; Samuel, Raymond E.; Hsu, Hu-Ping; Harris, Mitchel B.; Martin, Scott D.; Lee, Jean C.; Spector, Myron; Hammond, Paula T.en_US
dspace.mitauthor.errortrue
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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