Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials

Author(s)
Stephan, Matthias T.; Irvine, Darrell J
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Abstract
Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.
Date issued
2011-05
URI
http://hdl.handle.net/1721.1/99421
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Materials Science and Engineering; Ragon Institute of MGH, MIT and Harvard; Koch Institute for Integrative Cancer Research at MIT
Journal
Nano Today
Publisher
Elsevier
Citation
Stephan, Matthias T., and Darrell J. Irvine. “Enhancing Cell Therapies from the Outside in: Cell Surface Engineering Using Synthetic Nanomaterials.” Nano Today 6, no. 3 (June 2011): 309–325.
Version: Author's final manuscript
ISSN
17480132
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