dc.contributor.author | Hughes, Shannon Kay | |
dc.contributor.author | Lauffenburger, Douglas A. | |
dc.date.accessioned | 2015-10-27T16:19:34Z | |
dc.date.available | 2015-10-27T16:19:34Z | |
dc.date.issued | 2012-01 | |
dc.identifier.issn | 09550674 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/99475 | |
dc.description.abstract | Chemotaxis of tumor cells in response to a gradient of extracellular ligand is an important step in cancer metastasis. The heterogeneity of chemotactic responses in cancer has not been widely addressed by experimental or mathematical modeling techniques. However, recent advancements in chemoattractant presentation, fluorescent-based signaling probes, and phenotypic analysis paradigms provide rich sources for building data-driven relational models that describe tumor cell chemotaxis in response to a wide variety of stimuli. Here we present gradient sensing, and the resulting chemotactic behavior, in a ‘cue-signal-response’ framework and suggest methods for utilizing recently reported experimental methods in data-driven modeling ventures. | en_US |
dc.description.sponsorship | United States. Dept. of Defense. Breast Cancer Research Program (U.S.) (Fellowship BC087781) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant U54-CA112967) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R01-GM081336) | en_US |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.ceb.2012.01.001 | en_US |
dc.rights | Creative Commons Attribution | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | Quantitative analysis of gradient sensing: towards building predictive models of chemotaxis in cancer | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Hughes-Alford, Shannon K, and Douglas A Lauffenburger. “Quantitative Analysis of Gradient Sensing: Towards Building Predictive Models of Chemotaxis in Cancer.” Current Opinion in Cell Biology 24, no. 2 (April 2012): 284–291. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.mitauthor | Hughes, Shannon Kay | en_US |
dc.contributor.mitauthor | Lauffenburger, Douglas A. | en_US |
dc.relation.journal | Current Opinion in Cell Biology | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Hughes-Alford, Shannon K; Lauffenburger, Douglas A | en_US |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |