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dc.contributor.authorAlvarez-Dominguez, Juan R.
dc.contributor.authorHu, Wenqian
dc.contributor.authorGromatzky, Austin A.
dc.contributor.authorLodish, Harvey F.
dc.date.accessioned2015-10-27T17:31:20Z
dc.date.available2015-10-27T17:31:20Z
dc.date.issued2014-03
dc.date.submitted2014-01
dc.identifier.issn0925-5710
dc.identifier.issn1865-3774
dc.identifier.urihttp://hdl.handle.net/1721.1/99478
dc.description.abstractLong noncoding RNAs (lncRNAs) are increasingly recognized to contribute to cellular development via diverse mechanisms during both health and disease. Here, we highlight recent progress on the study of lncRNAs that function in the development of blood cells. We emphasize lncRNAs that regulate blood cell fates through epigenetic control of gene expression, an emerging theme among functional lncRNAs. Many of these noncoding genes and their targets become dysregulated during malignant hematopoiesis, directly implicating lncRNAs in blood cancers such as leukemia. In a few cases, dysregulation of an lncRNA alone leads to malignant hematopoiesis in a mouse model. Thus, lncRNAs may be not only useful as markers for the diagnosis and prognosis of cancers of the blood, but also as potential targets for novel therapies.en_US
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (Grant DK068348)en_US
dc.description.sponsorshipNational Heart, Lung, and Blood Institute (Grant 5P01 HL066105)en_US
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s12185-014-1552-8en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleLong noncoding RNAs during normal and malignant hematopoiesisen_US
dc.typeArticleen_US
dc.identifier.citationAlvarez-Dominguez, Juan R., Wenqian Hu, Austin A. Gromatzky, and Harvey F. Lodish. “Long Noncoding RNAs During Normal and Malignant Hematopoiesis.” Int J Hematol 99, no. 5 (March 9, 2014): 531–541.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorAlvarez-Dominguez, Juan R.en_US
dc.contributor.mitauthorLodish, Harvey F.en_US
dc.contributor.mitauthorGromatzky, Austin A.en_US
dc.relation.journalInternational Journal of Hematologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsAlvarez-Dominguez, Juan R.; Hu, Wenqian; Gromatzky, Austin A.; Lodish, Harvey F.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7029-7415
mit.licenseOPEN_ACCESS_POLICYen_US


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