Enhanced immune activation linked to endotoxemia in HIV-1 seronegative men who have sex with men

Author(s)
Palmer, Christine D.; Tomassilli, Julia; Sirignano, Michael; Romero-Tejeda, Marisol; Arnold, Kelly B.; ... Show more
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Alternative title
Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM
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Abstract
This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.
Date issued
2014-09
URI
http://hdl.handle.net/1721.1/99481
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Journal
AIDS
Publisher
Lippincott Williams & Wilkins
Citation
Palmer, Christine D., Julia Tomassilli, Michael Sirignano, Marisol Romero-Tejeda, Kelly B. Arnold, Denise Che, Douglas A. Lauffenburger, et al. “Enhanced Immune Activation Linked to Endotoxemia in HIV-1 Seronegative MSM.” AIDS 28, no. 14 (2014): 2162–2166.
Version: Author's final manuscript
ISSN
0269-9370
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