Enhanced immune activation linked to endotoxemia in HIV-1 seronegative men who have sex with men
Author(s)Palmer, Christine D.; Tomassilli, Julia; Sirignano, Michael; Romero-Tejeda, Marisol; Arnold, Kelly B.; Che, Denise; Lauffenburger, Douglas A.; Jost, Stephanie; Allen, Todd; Mayer, Kenneth H.; Altfeld, Marcus; ... Show more Show less
Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM
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This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Lippincott Williams & Wilkins
Palmer, Christine D., Julia Tomassilli, Michael Sirignano, Marisol Romero-Tejeda, Kelly B. Arnold, Denise Che, Douglas A. Lauffenburger, et al. “Enhanced Immune Activation Linked to Endotoxemia in HIV-1 Seronegative MSM.” AIDS 28, no. 14 (2014): 2162–2166.
Author's final manuscript