An efficient system for the Pd-catalyzed cross-coupling of amides and aryl chlorides
Author(s)Fors, Brett P.; Dooleweerdt, Karin; Zeng, Qingle; Buchwald, Stephen Leffler
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A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent. An array of amides and aryl chlorides were successfully reacted in good to excellent yields.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Fors, Brett P., Karin Dooleweerdt, Qingle Zeng, and Stephen L. Buchwald. “An Efficient System for the Pd-Catalyzed Cross-Coupling of Amides and Aryl Chlorides.” Tetrahedron 65, no. 33 (August 2009): 6576–6583.
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