Show simple item record

dc.contributor.authorLi, Jonathan Z.
dc.contributor.authorArnold, Kelly B.
dc.contributor.authorLo, Janet
dc.contributor.authorDugast, Anne-Sophie
dc.contributor.authorPlants, Jill
dc.contributor.authorRibaudo, Heather J.
dc.contributor.authorCesa, Kevin
dc.contributor.authorHeisey, Andrea
dc.contributor.authorKuritzkes, Daniel R.
dc.contributor.authorLauffenburger, Douglas A.
dc.contributor.authorAlter, Galit
dc.contributor.authorLanday, Alan
dc.contributor.authorGrinspoon, Steven
dc.contributor.authorPereyra, Florencia
dc.date.accessioned2015-10-29T13:58:15Z
dc.date.available2015-10-29T13:58:15Z
dc.date.issued2014-12
dc.date.submitted2014-08
dc.identifier.issn2328-8957
dc.identifier.urihttp://hdl.handle.net/1721.1/99496
dc.description.abstractBackground. Human immunodeficiency virus (HIV)-1 elite controllers (ECs) represent an ideal population to study the effects of HIV persistence on chronic inflammation in the absence of antiretroviral therapy (ART). Methods. Twenty inflammatory markers measured in cohorts of ECs, HIV suppressed noncontrollers, and HIV-uninfected controls were compared using rank-based tests and partial least squares discriminant analysis (PLSDA). Spearman correlations were determined among the inflammatory markers, residual viremia by the single-copy assay, and CD4[superscript +] T cell slope. Results. Significant differences were seen between cohorts in 15 of the soluble inflammatory markers. Human immunodeficiency virus-1 ECs were found to have the highest levels for all of the markers with the exception of RANTES. In particular, median levels of 7 inflammatory markers (soluble CD14 [sCD14], interferon [IFN]-γ, IFN-γ-inducible protein [IP]-10, interleukin [IL]-4, IL-10, sCD40L, and granulocyte-macrophage colony-stimulating factor) were twice as high in the HIV-1 ECs compared with either of the HIV-suppressed or uninfected groups. Multivariate PLSDA analysis of inflammatory markers improved differentiation between the patient cohorts, discerning gender differences in inflammatory profile amongst individuals on suppressive ART. Soluble markers of inflammation in ECs were not associated with either levels of residual HIV-1 viremia or CD4[superscript +] T cell decline. Conclusions. Despite maintaining relatively low levels of viremia, HIV-1 ECs had elevated levels of a set of key inflammatory markers. Additional studies are needed to determine whether ECs may benefit from ART and to further evaluate the observed gender differences.en_US
dc.description.sponsorshipBill & Melinda Gates Foundationen_US
dc.description.sponsorshipAIDS Healthcare Foundationen_US
dc.description.sponsorshipHarvard University. Center for AIDS Researchen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH P30 AI060354)en_US
dc.description.sponsorshipRagon Institute of MGH, MIT and Harvard (Postdoctoral Fellowship)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (U19-AI0859)en_US
dc.language.isoen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1093/ofid/ofu117en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceOpen Forum Infectious Diseasesen_US
dc.titleDifferential Levels of Soluble Inflammatory Markers by Human Immunodeficiency Virus Controller Status and Demographicsen_US
dc.typeArticleen_US
dc.identifier.citationLi, J. Z., K. B. Arnold, J. Lo, A.-S. Dugast, J. Plants, H. J. Ribaudo, K. Cesa, et al. “Differential Levels of Soluble Inflammatory Markers by Human Immunodeficiency Virus Controller Status and Demographics.” Open Forum Infectious Diseases 2, no. 1 (December 16, 2014): ofu117–ofu117.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.mitauthorArnold, Kelly B.en_US
dc.contributor.mitauthorLauffenburger, Douglas A.en_US
dc.relation.journalOpen Forum Infectious Diseasesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLi, J. Z.; Arnold, K. B.; Lo, J.; Dugast, A.-S.; Plants, J.; Ribaudo, H. J.; Cesa, K.; Heisey, A.; Kuritzkes, D. R.; Lauffenburger, D. A.; Alter, G.; Landay, A.; Grinspoon, S.; Pereyra, F.en_US
mit.licensePUBLISHER_CCen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record