Lithiation and electrophilic substitution of dimethyl triazones
Author(s)Han, Sunkyu; Siegel, Dustin S.; Movassaghi, Mohammad
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The lithiation and electrophilic substitution of dimethyl triazones is described. Directed lithiation or tin–lithium exchange of dimethyl triazones afforded the corresponding dipole stabilized nucleophiles that were trapped with various electrophiles. Keto-triazone derivatives accessed by acylation of such nucleophiles were readily converted into the corresponding imidazolone heterocycles.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Han, Sunkyu, Dustin S. Siegel, and Mohammad Movassaghi. “Lithiation and Electrophilic Substitution of Dimethyl Triazones.” Tetrahedron Letters 53, no. 29 (July 2012): 3722–3726.
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