dc.contributor.author | White, Forest M. | |
dc.contributor.author | Gajadhar, Aaron | |
dc.date.accessioned | 2015-10-30T17:58:23Z | |
dc.date.available | 2015-10-30T17:58:23Z | |
dc.date.issued | 2014-01 | |
dc.identifier.issn | 09581669 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/99531 | |
dc.description.abstract | Attempts to characterize cellular behaviors with static, univariate measurements cannot fully capture biological complexity and lead to an inadequate interpretation of cellular processes. Significant biological insight can be gleaned by considering the contribution of dynamic protein post-translational modifications (PTMs) utilizing systems-level quantitative analysis. High-resolution mass spectrometry coupled with computational modeling of dynamic signal–response relationships is a powerful tool to reveal PTM-mediated regulatory networks. Recent advances using this approach have defined network kinetics of growth factor signaling pathways, identified systems level responses to cytotoxic perturbations, elucidated kinase–substrate relationships, and unraveled the dynamics of PTM cross-talk. Innovations in multiplex measurement capacity, PTM annotation accuracy, and computational integration of datasets promise enhanced resolution of dynamic PTM networks and further insight into biological intricacies. | en_US |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.copbio.2013.12.009 | en_US |
dc.rights | Creative Commons Attribution | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | System level dynamics of post-translational modifications | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Gajadhar, Aaron S, and Forest M White. “System Level Dynamics of Post-Translational Modifications.” Current Opinion in Biotechnology 28 (August 2014): 83–87. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
dc.contributor.mitauthor | Gajadhar, Aaron S. | en_US |
dc.contributor.mitauthor | White, Forest M. | en_US |
dc.relation.journal | Current Opinion in Biotechnology | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Gajadhar, Aaron S; White, Forest M | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-1545-1651 | |
dc.identifier.orcid | https://orcid.org/0000-0002-5782-9544 | |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |