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dc.contributor.authorNiljianskul, Nootaree
dc.contributor.authorZhu, Shaolin
dc.contributor.authorBuchwald, Stephen Leffler
dc.date.accessioned2015-11-02T19:07:55Z
dc.date.available2015-11-02T19:07:55Z
dc.date.issued2014-12
dc.date.submitted2014-10
dc.identifier.issn14337851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/1721.1/99658
dc.description.abstractThe synthesis of α-aminosilanes by a highly enantio- and regioselective copper-catalyzed hydroamination of vinylsilanes is reported. The system employs Cu-DTBM-SEGPHOS as the catalyst, diethoxymethylsilane as the stoichiometric reductant, and O-benzoylhydroxylamines as the electrophilic nitrogen source. This hydroamination reaction is compatible with differentially substituted vinylsilanes, thus providing access to amino acid mimics and other valuable chiral organosilicon compounds.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Award GM58160)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201410326en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleEnantioselective Synthesis of α-Aminosilanes by Copper-Catalyzed Hydroamination of Vinylsilanesen_US
dc.typeArticleen_US
dc.identifier.citationNiljianskul, Nootaree, Shaolin Zhu, and Stephen L. Buchwald. “Enantioselective Synthesis of α-Aminosilanes by Copper-Catalyzed Hydroamination of Vinylsilanes.” Angew. Chem. Int. Ed. 54, no. 5 (December 4, 2014): 1638–1641.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorNiljianskul, Nootareeen_US
dc.contributor.mitauthorZhu, Shaolinen_US
dc.contributor.mitauthorBuchwald, Stephen Leffleren_US
dc.relation.journalAngewandte Chemie International Editionen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsNiljianskul, Nootaree; Zhu, Shaolin; Buchwald, Stephen L.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-3875-4775
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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