Copper-Catalyzed Regioselective Ortho C-H Cyanation of Vinylarenes

Author(s)
Yang, Yang; Buchwald, Stephen Leffler
Thumbnail
DownloadBuckwald_Copper-catalyzed.pdf (709.3Kb)
OPEN_ACCESS_POLICY
Terms of use
Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/
Metadata
Show full item record
Abstract
A copper-based catalytic technique for the regioselective ortho C-H cyanation of vinylarenes has been developed. This method provides an effective means for the selective functionalization of vinylarene derivatives. A copper-catalyzed cyanative dearomatization mechanism is proposed to account for the regiochemical course of this reaction.
Date issued
2014-05
URI
http://hdl.handle.net/1721.1/99668
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Yang, Yang, and Stephen L. Buchwald. “Copper-Catalyzed Regioselective Ortho C-H Cyanation of Vinylarenes.” Angew. Chem. Int. Ed. 53, no. 33 (May 6, 2014): 8677–8681.
Version: Author's final manuscript
ISSN
14337851
1521-3773
Collections