| dc.contributor.author | Shi, Shi-Liang | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2015-11-03T12:53:55Z | |
| dc.date.available | 2015-11-03T12:53:55Z | |
| dc.date.issued | 2014-12 | |
| dc.identifier.issn | 14337851 | |
| dc.identifier.issn | 1521-3773 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/99673 | |
| dc.description.abstract | The synthesis of 3,3-difluoro-2-oxindoles through a robust and efficient palladium-catalyzed C-H difluoroalkylation is described. This process generates a broad range of difluorooxindoles from readily prepared starting materials. The use of BrettPhos as the ligand was crucial for high efficiency. Preliminary mechanistic studies suggest that oxidative addition is the rate-determining step for this process. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (GM46059) | en_US |
| dc.description.sponsorship | Japan Society for the Promotion of Science (Fellowship) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Wiley Blackwell | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1002/anie.201410471 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Palladium-Catalyzed Intramolecular C-H Difluoroalkylation: Synthesis of Substituted 3,3-Difluoro-2-oxindoles | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Shi, Shi-Liang, and Stephen L. Buchwald. “Palladium-Catalyzed Intramolecular C-H Difluoroalkylation: Synthesis of Substituted 3,3-Difluoro-2-Oxindoles.” Angew. Chem. Int. Ed. 54, no. 5 (December 4, 2014): 1646–1650. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Shi, Shi-Liang | en_US |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | en_US |
| dc.relation.journal | Angewandte Chemie International Edition | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Shi, Shi-Liang; Buchwald, Stephen L. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-7917-7620 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
