| dc.contributor.author | Zhu, Shaolin | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2015-11-03T13:12:22Z | |
| dc.date.available | 2015-11-03T13:12:22Z | |
| dc.date.issued | 2014-10 | |
| dc.date.submitted | 2014-09 | |
| dc.identifier.issn | 0002-7863 | |
| dc.identifier.issn | 1520-5126 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/99676 | |
| dc.description.abstract | Enantioselective synthesis of β-chiral amines has been achieved via copper-catalyzed hydroamination of 1,1-disubstituted alkenes with hydroxylamine esters in the presence of a hydrosilane. This mild process affords a range of structurally diverse β-chiral amines, including β-deuterated amines, in excellent yields with high enantioselectivities. Furthermore, catalyst loading as low as 0.4 mol% could be employed to deliver product in undiminished yield and selectivity, demonstrating the practicality of this method for large-scale synthesis. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Award GM58160) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ja509786v | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | ACS | en_US |
| dc.title | Enantioselective CuH-Catalyzed Anti-Markovnikov Hydroamination of 1,1-Disubstituted Alkenes | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Zhu, Shaolin, and Stephen L. Buchwald. “Enantioselective CuH-Catalyzed Anti-Markovnikov Hydroamination of 1,1-Disubstituted Alkenes.” Journal of the American Chemical Society 136, no. 45 (November 12, 2014): 15913–15916. © 2014 American Chemical Society | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Zhu, Shaolin | en_US |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | en_US |
| dc.relation.journal | Journal of the American Chemical Society | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Zhu, Shaolin; Buchwald, Stephen L. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
