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dc.contributor.authorHui, Elliot E.
dc.contributor.authorLi, Chun
dc.contributor.authorAgrawal, Amit
dc.contributor.authorBhatia, Sangeeta N.
dc.date.accessioned2015-11-10T13:04:17Z
dc.date.available2015-11-10T13:04:17Z
dc.date.issued2014-03
dc.date.submitted2013-07
dc.identifier.issn1057-7157
dc.identifier.issn1941-0158
dc.identifier.urihttp://hdl.handle.net/1721.1/99869
dc.description.abstractThe spatial organization of cellular communities plays a fundamental role in determining intercellular communication and emergent behavior. Few tools, however, exist to modulate tissue organization at the scale of individual cells, particularly in the case of dynamic manipulation. Micromechanical reconfigurable culture achieves dynamic control of tissue organization by culturing adherent cells on microfabricated plates that can be shifted to reorganize the arrangement of the cells. Although biological studies using this approach have been previously reported, this paper focuses on the engineering of the device, including the mechanism for translating manual manipulation to precise microscale position control, fault-tolerant design for manufacture, and the synthetic-to-living interface.en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Faculty Early Career Development Program)en_US
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.)en_US
dc.description.sponsorshipDavid & Lucile Packard Foundationen_US
dc.description.sponsorshipNational Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Awarden_US
dc.language.isoen_US
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1109/jmems.2013.2278813en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleMacro-to-Micro Interface for the Control of Cellular Organizationen_US
dc.typeArticleen_US
dc.identifier.citationHui, Elliot E., Chun Li, Amit Agrawal, and Sangeeta N. Bhatia. “Macro-to-Micro Interface for the Control of Cellular Organization.” J. Microelectromech. Syst. 23, no. 2 (April 2014): 391–397.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorHui, Elliot E.en_US
dc.contributor.mitauthorLi, Chunen_US
dc.contributor.mitauthorAgrawal, Amiten_US
dc.contributor.mitauthorBhatia, Sangeeta N.en_US
dc.relation.journalJournal of Microelectromechanical Systemsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsHui, Elliot E.; Li, Chun; Agrawal, Amit; Bhatia, Sangeeta N.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1293-2097
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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