Design Considerations for Tumor-Targeted Nanoparticles
Author(s)
Choi, Hak Soo; Liu, Wenhao; Liu, Fangbing; Nasr, Khaled; Misra, Preeti; Bawendi, Moungi G.; Frangioni, John V.; ... Show more Show less
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Inorganic/organic hybrid nanoparticles are potentially useful in biomedicine, but to avoid non-specific background fluorescence and long-term toxicity, they need to be cleared from the body within a reasonable timescale1. Previously, we have shown that rigid spherical nanoparticles such as quantum dots can be cleared by the kidneys if they have a hydrodynamic diameter of approximately 5.5 nm and a zwitterionic surface charge2. Here, we show that quantum dots functionalized with high-affinity small-molecule ligands that target tumours can also be cleared by the kidneys if their hydrodynamic diameter is less than this value, which sets an upper limit of 5–10 ligands per quantum dot for renal clearance. Animal models of prostate cancer and melanoma show receptor-specific imaging and renal clearance within 4 h post-injection. This study suggests a set of design rules for the clinical translation of targeted nanoparticles that can be eliminated through the kidneys.
Date issued
2009-11Department
Massachusetts Institute of Technology. Department of ChemistryJournal
Nature Nanotechnology
Publisher
Nature Publishing Group
Citation
Choi, Hak Soo et al. “Design Considerations for Tumour-targeted Nanoparticles.” Nature Nanotechnology 5.1 (2009): 42–47. Web.
Version: Author's final manuscript
ISSN
1748-3387
1748-3395