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Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm

Author(s)
Lee, Kichang; Lv, Wener; Ter-Ovanesyan, Evgeny; Barley, Maya E.; Voysey, Graham E.; Galea, Anna M.; Hirschman, Gordon B.; Leroy, Kristen; Marini, Robert P.; Barrett, Conor; Armoundas, Antonis A.; Cohen, Richard J.; ... Show more Show less
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Abstract
Background We developed and evaluated a novel system for guiding radiofrequency catheter ablation therapy of ventricular tachycardia. This guidance system employs an inverse solution guidance algorithm (ISGA) using a single equivalent moving dipole (SEMD) localization method. The method and system were evaluated in both a saline tank phantom model and in vivo animal (swine) experiments. Methods A catheter with two platinum electrodes spaced 3 mm apart was used as the dipole source in the phantom study. A 40-Hz sinusoidal signal was applied to the electrode pair. In the animal study, four to eight electrodes were sutured onto the right ventricle. These electrodes were connected to a stimulus generator delivering 1-ms duration pacing pulses. Signals were recorded from 64 electrodes, located either on the inner surface of the saline tank or on the body surface of the pig, and then processed by the ISGA to localize the physical or bioelectrical SEMD. Results In the phantom studies, the guidance algorithm was used to advance a catheter tip to the location of the source dipole. The distance from the final position of the catheter tip to the position of the target dipole was 2.22 ± 0.78 mm in real space and 1.38 ± 0.78 mm in image space (computational space). The ISGA successfully tracked the locations of electrodes sutured on the ventricular myocardium and the movement of an endocardial catheter placed in the animal's right ventricle. Conclusion In conclusion, we successfully demonstrated the feasibility of using an SEMD inverse algorithm to guide a cardiac ablation catheter.
Date issued
2013-02
URI
http://hdl.handle.net/1721.1/102579
Department
Institute for Medical Engineering and Science; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Mechanical Engineering; Massachusetts Institute of Technology. Division of Comparative Medicine
Journal
Pacing and Clinical Electrophysiology
Publisher
Wiley Blackwell
Citation
Lee, Kichang, Wener Lv, Evgeny Ter-Ovanesyan, Maya E. Barley, Graham E. Voysey, Anna M. Galea, Gordon B. Hirschman, et al. “Cardiac Ablation Catheter Guidance by Means of a Single Equivalent Moving Dipole Inverse Algorithm.” Pacing and Clinical Electrophysiology 36, no. 7 (July 2013): 811–22.
Version: Author's final manuscript
ISSN
01478389
1540-8159

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