Browsing MIT Open Access Articles by Title
Now showing items 36533-36552 of 55934
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P III /P V =O Catalyzed Cascade Synthesis of N‐Functionalized Azaheterocycles
(Wiley, 2020)© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. ... -
P III /P V ═O-Catalyzed Intermolecular N–N Bond Formation: Cross-Selective Reductive Coupling of Nitroarenes and Anilines
(American Chemical Society (ACS), 2021)An organophosphorus-catalyzed method for the synthesis of unsymmetrical hydrazines by cross-selective intermolecular N-N reductive coupling is reported. This method employs a small ring phosphacycle (phosphetane) catalyst ... -
P recision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads
(EMBO, 2020)© 2020 The Authors. Published under the terms of the CC BY 4.0 license Genetic circuits have many applications, from guiding living therapeutics to ordering process in a bioreactor, but to be useful they have to be genetically ... -
P(III)/P(V)-Catalyzed Methylamination of Arylboronic Acids and Esters: Reductive C–N Coupling with Nitromethane as a Methylamine Surrogate
(American Chemical Society (ACS), 2020)Copyright © 2020 American Chemical Society. The direct reductive N-arylation of nitromethane by organophosphorus-catalyzed reductive C-N coupling with arylboronic acid derivatives is reported. This method operates by the ... -
p-adic dimensions in symmetric tensor categories in characteristic p
(European Mathematical Publishing House, 2018-02)To every object X of a symmetric tensor category over a field of characteristic p > 0 we attach p-adic integers Dim+(X) and Dim−(X) whose reduction modulo p is the categorical dimension dim(X) of X, coinciding with the ... -
p-adic interpolation of iterates
(Oxford University Press, 2014-03)Extending work of Bell and of Bell, Ghioca, and Tucker, we prove that for a p-adic analytic self-map f on a closed unit polydisk, if every coefficient of f(x)−x has valuation greater than that of p [1over (p−1)], then the ... -
The P-Norm Push: A Simple Convex Ranking Algorithm that Concentrates at the Top of the List
(MIT Press, 2009-10)We are interested in supervised ranking algorithms that perform especially well near the top of the ranked list, and are only required to perform sufficiently well on the rest of the list. In this work, we provide a ... -
The p-parity conjecture for elliptic curves with a p-isogeny
(Walter de Gruyter, 2014-06)For an elliptic curve E over a number field K, one consequence of the Birch and Swinnerton-Dyer conjecture is the parity conjecture: the global root number matches the parity of the Mordell-Weil rank. Assuming finiteness ... -
P-Wave ππ Scattering and the ρ Resonance from Lattice QCD
(2017-08)We calculate the parameters describing elastic I=1, P-wave ππ scattering using lattice QCD with 2+1 flavors of clover fermions. Our calculation is performed with a pion mass of m[subscript π]≈320 MeV and a lattice size of ... -
P-wave ππ scattering and the ρ resonance from lattice QCD
(American Physical Society, 2017-08)We calculate the parameters describing elastic I=1, P-wave ππ scattering using lattice QCD with 2+1 flavors of clover fermions. Our calculation is performed with a pion mass of m[subscript π]≈320 MeV and a lattice size ... -
A p38alpha-Selective Chemosensor for use in Unfractionated Cell Lysates
(American Chemical Society, 2010-09)Recent efforts have identified the p38alpha Ser/Thr kinase as a potential target for the treatment of inflammatory diseases as well as non-small cell lung carcinoma. Despite the significance of p38alpha, no direct activity ... -
The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death
(Nature Publishing Group, 2015-06)The tumour suppressor p53 is an important mediator of cell cycle arrest and apoptosis in response to DNA damage, acting mainly by transcriptional regulation of specific target genes. The exact details how p53 modulates ... -
p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer
(National Academy of Sciences (U.S.), 2014-04)Anaplastic thyroid carcinoma (ATC) has among the worst prognoses of any solid malignancy. The low incidence of the disease has in part precluded systematic clinical trials and tissue collection, and there has been little ... -
p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis
(American Association for the Advancement of Science (AAAS), 2009-12)Acute exposure to ionizing radiation can cause lethal damage to the gastrointestinal (GI) tract, a condition called the GI syndrome. Whether the target cells affected by radiation to cause the GI syndrome are derived from ... -
p53 null Fluorescent Yellow Direct Repeat (FYDR) mice have normal levels of homologous recombination
(Elsevier B.V., 2011-12)The tumor suppressor p53 is a transcription factor whose function is critical for maintaining genomic stability in mammalian cells. In response to DNA damage, p53 initiates a signaling cascade that results in cell cycle ... -
p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair
(Public Library of Science, 2009-10)The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that ... -
Pace of shifts in climate regions increases with global temperature
(Nature Publishing Group, 2013-04)Human-induced climate change causes significant changes in local climates, which in turn lead to changes in regional climate zones. Large shifts in the world distribution of Köppen–Geiger climate classifications by the end ... -
Pachinko
(Elsevier BV, 2017-07)Inspired by the Japanese game Pachinko, we study simple (perfectly “inelastic” collisions) dynamics of a unit ball falling amidst point obstacles (pins) in the plane. A classic example is that a checkerboard grid of pins ... -
Pacific Shallow Meridional Overturning Circulation in a Warming Climate
(American Meteorological Society, 2011-12)By analyzing a set of the Coupled Model Intercomparison Project phase 3 (CMIP3) climate model projections of the twenty-first century, it is found that the shallow meridional overturning of the Pacific subtropical cells ... -
Packaged 1.5- \mu m Quantum-Well SOA With 0.8-W Output Power and 5.5-dB Noise Figure
(Institute of Electrical and Electronics Engineers, 2009-08)We report the demonstration of a lensed-fiber-pigtailed InGaAsP-InP quantum-well semiconductor optical amplifier based on the slab-coupled optical waveguide (SCOW) concept. At a 5-A bias current and a wavelength of 1540 ...
