MIT Open Access Articles: Recent submissions
Now showing items 1-3 of 54497
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Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
(Elsevier BV, 2023-07-20)Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine boosting of CAR T cells triggers the ... -
Early cellular and molecular signatures correlate with severity of West Nile virus infection
(Elsevier BV, 2023-12-15)Infection with West Nile virus (WNV) drives a wide range of responses, from asymptomatic to flu-like symptoms/fever or severe cases of encephalitis and death. To identify cellular and molecular signatures distinguishing ... -
Full-length single-cell BCR sequencing paired with RNA sequencing reveals convergent responses to pneumococcal vaccination
(Springer Science and Business Media LLC, 2024-09-28)Single-cell RNA sequencing (scRNA-seq) can resolve transcriptional features from individual cells, but scRNA-seq techniques capable of resolving the variable regions of B cell receptors (BCRs) remain limited, especially ...