Me[subscript 3](OMe)tBuXPhos: A Surrogate Ligand for Me[subscript 4]tBuXPhos in Palladium-Catalyzed C-N and C-O Bond-Forming Reactions
Author(s)
Ueda, Satoshi; Fors, Brett P.; Ali, Siraj Z.; Buchwald, Stephen Leffler
DownloadBuchwald_Me-3 (Ome).pdf (830.6Kb)
PUBLISHER_POLICY
Publisher Policy
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Terms of use
Metadata
Show full item recordAbstract
A new biarylphosphine ligand, Me[subscript 3](OMe)tBuXPhos (L3), was designed as a surrogate for Me[subscript 4]tBuXPhos (L1). The Me[subscript 3](OMe)tBuXPhos could be prepared in a chromatography-free manner from inexpensive and readily available 2,3,6-trimethylphenol. Comparative studies demonstrated that a catalyst based on Me[subscript 3](OMe)tBuXPhos displayed the same reactivity as a catalyst based on Me[subscript 4]tBuXPhos for Pd-catalyzed C–N and C–O bond-forming processes.
Date issued
2012-02Department
Massachusetts Institute of Technology. Department of ChemistryJournal
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Citation
Ueda, Satoshi, Siraj Ali, Brett P. Fors, and Stephen L. Buchwald. “Me3(OMe)tBuXPhos: A Surrogate Ligand for Me4tBuXPhos in Palladium-Catalyzed C–N and C–O Bond-Forming Reactions.” The Journal of Organic Chemistry 77, no. 5 (March 2, 2012): 2543-2547.
Version: Author's final manuscript
ISSN
0022-3263
1520-6904