Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn's Disease and Ulcerative Colitis
Author(s)
Ananthakrishnan, Ashwin N.; Gainer, Vivian; Cai, Tianxi; Perez, Raul Guzman; Cheng, Su-Chun; Savova, Guergana; Chen, Pei; Szolovits, Peter; Xia, Zongqi; De Jager, Philip L.; Shaw, Stanley; Churchill, Susanne; Karlson, Elizabeth W.; Kohane, Isaac; Perlis, Roy H.; Plenge, Robert M.; Murphy, Shawn N.; Liao, Katherine P.; ... Show more Show less
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OBJECTIVES:
Psychiatric comorbidity is common in Crohn's disease (CD) and ulcerative colitis (UC). Inflammatory bowel disease (IBD)-related surgery or hospitalizations represent major events in the natural history of the disease. The objective of this study is to examine whether there is a difference in the risk of psychiatric comorbidity following surgery in CD and UC.
METHODS:
We used a multi-institution cohort of IBD patients without a diagnosis code for anxiety or depression preceding their IBD-related surgery or hospitalization. Demographic-, disease-, and treatment-related variables were retrieved. Multivariate logistic regression analysis was performed to individually identify risk factors for depression and anxiety.
RESULTS:
Our study included a total of 707 CD and 530 UC patients who underwent bowel resection surgery and did not have depression before surgery. The risk of depression 5 years after surgery was 16% and 11% in CD and UC patients, respectively. We found no difference in the risk of depression following surgery in the CD and UC patients (adjusted odds ratio, 1.11; 95% confidence interval, 0.84–1.47). Female gender, comorbidity, immunosuppressant use, perianal disease, stoma surgery, and early surgery within 3 years of care predicted depression after CD surgery; only the female gender and comorbidity predicted depression in UC patients. Only 12% of the CD cohort had ≥4 risk factors for depression, but among them nearly 44% subsequently received a diagnosis code for depression.
CONCLUSIONS:
IBD-related surgery or hospitalization is associated with a significant risk for depression and anxiety, with a similar magnitude of risk in both diseases.
Date issued
2013-01Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer ScienceJournal
The American Journal of Gastroenterology
Publisher
Nature Publishing Group
Citation
Ananthakrishnan, Ashwin N, Vivian S Gainer, Tianxi Cai, Raul Guzman Perez, Su-Chun Cheng, Guergana Savova, Pei Chen, et al. “Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn’s Disease and Ulcerative Colitis.” Am J Gastroenterol 108, no. 4 (January 22, 2013): 594–601.
Version: Author's final manuscript
ISSN
0002-9270
1572-0241