dc.contributor.author | Ananthakrishnan, Ashwin N. | |
dc.contributor.author | Gainer, Vivian | |
dc.contributor.author | Cai, Tianxi | |
dc.contributor.author | Perez, Raul Guzman | |
dc.contributor.author | Cheng, Su-Chun | |
dc.contributor.author | Savova, Guergana | |
dc.contributor.author | Chen, Pei | |
dc.contributor.author | Szolovits, Peter | |
dc.contributor.author | Xia, Zongqi | |
dc.contributor.author | De Jager, Philip L. | |
dc.contributor.author | Shaw, Stanley | |
dc.contributor.author | Churchill, Susanne | |
dc.contributor.author | Karlson, Elizabeth W. | |
dc.contributor.author | Kohane, Isaac | |
dc.contributor.author | Perlis, Roy H. | |
dc.contributor.author | Plenge, Robert M. | |
dc.contributor.author | Murphy, Shawn N. | |
dc.contributor.author | Liao, Katherine P. | |
dc.date.accessioned | 2014-10-14T19:18:15Z | |
dc.date.available | 2014-10-14T19:18:15Z | |
dc.date.issued | 2013-01 | |
dc.date.submitted | 2012-10 | |
dc.identifier.issn | 0002-9270 | |
dc.identifier.issn | 1572-0241 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/90916 | |
dc.description.abstract | OBJECTIVES:
Psychiatric comorbidity is common in Crohn's disease (CD) and ulcerative colitis (UC). Inflammatory bowel disease (IBD)-related surgery or hospitalizations represent major events in the natural history of the disease. The objective of this study is to examine whether there is a difference in the risk of psychiatric comorbidity following surgery in CD and UC.
METHODS:
We used a multi-institution cohort of IBD patients without a diagnosis code for anxiety or depression preceding their IBD-related surgery or hospitalization. Demographic-, disease-, and treatment-related variables were retrieved. Multivariate logistic regression analysis was performed to individually identify risk factors for depression and anxiety.
RESULTS:
Our study included a total of 707 CD and 530 UC patients who underwent bowel resection surgery and did not have depression before surgery. The risk of depression 5 years after surgery was 16% and 11% in CD and UC patients, respectively. We found no difference in the risk of depression following surgery in the CD and UC patients (adjusted odds ratio, 1.11; 95% confidence interval, 0.84–1.47). Female gender, comorbidity, immunosuppressant use, perianal disease, stoma surgery, and early surgery within 3 years of care predicted depression after CD surgery; only the female gender and comorbidity predicted depression in UC patients. Only 12% of the CD cohort had ≥4 risk factors for depression, but among them nearly 44% subsequently received a diagnosis code for depression.
CONCLUSIONS:
IBD-related surgery or hospitalization is associated with a significant risk for depression and anxiety, with a similar magnitude of risk in both diseases. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (U54-LM008748) | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/ajg.2012.471 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn's Disease and Ulcerative Colitis | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Ananthakrishnan, Ashwin N, Vivian S Gainer, Tianxi Cai, Raul Guzman Perez, Su-Chun Cheng, Guergana Savova, Pei Chen, et al. “Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn’s Disease and Ulcerative Colitis.” Am J Gastroenterol 108, no. 4 (January 22, 2013): 594–601. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science | en_US |
dc.contributor.mitauthor | Szolovits, Peter | en_US |
dc.relation.journal | The American Journal of Gastroenterology | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Ananthakrishnan, Ashwin N; Gainer, Vivian S; Cai, Tianxi; Perez, Raul Guzman; Cheng, Su-Chun; Savova, Guergana; Chen, Pei; Szolovits, Peter; Xia, Zongqi; De Jager, Philip L; Shaw, Stanley; Churchill, Susanne; Karlson, Elizabeth W; Kohane, Isaac; Perlis, Roy H; Plenge, Robert M; Murphy, Shawn N; Liao, Katherine P | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-8411-6403 | |
mit.license | OPEN_ACCESS_POLICY | en_US |
mit.metadata.status | Complete | |