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dc.contributor.authorD’Alessio, Ana C.
dc.contributor.authorFan, Zi Peng
dc.contributor.authorWert, Katherine J.
dc.contributor.authorBaranov, Petr
dc.contributor.authorCohen, Malkiel A.
dc.contributor.authorSaini, Janmeet S.
dc.contributor.authorCohick, Evan
dc.contributor.authorCharniga, Carol
dc.contributor.authorHannett, Nancy M.
dc.contributor.authorYoung, Michael J.
dc.contributor.authorTemple, Sally
dc.contributor.authorJaenisch, Rudolf
dc.contributor.authorLee, Tong Ihn
dc.contributor.authorYoung, Richard A.
dc.contributor.authorDadon, Daniel Benjamin
dc.contributor.authorYoung, Richard A.
dc.date.accessioned2016-01-13T16:39:08Z
dc.date.available2016-01-13T16:39:08Z
dc.date.issued2015-10
dc.date.submitted2015-09
dc.identifier.issn22136711
dc.identifier.urihttp://hdl.handle.net/1721.1/100808
dc.description.abstractHundreds of transcription factors (TFs) are expressed in each cell type, but cell identity can be induced through the activity of just a small number of core TFs. Systematic identification of these core TFs for a wide variety of cell types is currently lacking and would establish a foundation for understanding the transcriptional control of cell identity in development, disease, and cell-based therapy. Here, we describe a computational approach that generates an atlas of candidate core TFs for a broad spectrum of human cells. The potential impact of the atlas was demonstrated via cellular reprogramming efforts where candidate core TFs proved capable of converting human fibroblasts to retinal pigment epithelial-like cells. These results suggest that candidate core TFs from the atlas will prove a useful starting point for studying transcriptional control of cell identity and reprogramming in many human cell types.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant HG002668)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant CA146445)en_US
dc.description.sponsorshipSkolkovo Institute of Science and Technologyen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.stemcr.2015.09.016en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceElsevieren_US
dc.titleA Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identityen_US
dc.typeArticleen_US
dc.identifier.citationD’Alessio, Ana C., Zi Peng Fan, Katherine J. Wert, Petr Baranov, Malkiel A. Cohen, Janmeet S. Saini, Evan Cohick, et al. “A Systematic Approach to Identify Candidate Transcription Factors That Control Cell Identity.” Stem Cell Reports 5, no. 5 (November 2015): 763–775.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorDadon, Daniel Benjaminen_US
dc.contributor.mitauthorJaenisch, Rudolfen_US
dc.contributor.mitauthorYoung, Richard A.en_US
dc.relation.journalStem Cell Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsD’Alessio, Ana C.; Fan, Zi Peng; Wert, Katherine J.; Baranov, Petr; Cohen, Malkiel A.; Saini, Janmeet S.; Cohick, Evan; Charniga, Carol; Dadon, Daniel; Hannett, Nancy M.; Young, Michael J.; Temple, Sally; Jaenisch, Rudolf; Lee, Tong Ihn; Young, Richard A.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7256-3158
dc.identifier.orcidhttps://orcid.org/0000-0001-8855-8647
mit.licenseOPEN_ACCESS_POLICYen_US


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