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Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

dc.contributor.authorDong, Yizhou
dc.contributor.authorEltoukhy, Ahmed A.
dc.contributor.authorAlabi, Christopher A.
dc.contributor.authorVeiseh, Omid
dc.contributor.authorSirirungruang, Sasilada
dc.contributor.authorYin, Hao
dc.contributor.authorTang, Benjamin C.
dc.contributor.authorChen, Delai
dc.contributor.authorGu, Zhen
dc.contributor.authorXue, Yuan
dc.contributor.authorAnderson, Daniel Griffith
dc.contributor.authorPelet, Jeisa
dc.contributor.authorLanger, Robert S
dc.contributor.authorKhan, Omar Fizal
dc.contributor.authorDorkin, Joseph Robert
dc.date.accessioned2016-02-09T16:06:51Z
dc.date.available2016-02-09T16:06:51Z
dc.date.issued2014-03
dc.date.submitted2014-01
dc.identifier.issn21922640
dc.identifier.urihttp://hdl.handle.net/1721.1/101132
dc.description.abstractNew lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Center of Cancer Nanotechnology Excellence at MIT-Harvard U54-CA151884)en_US
dc.description.sponsorshipNational Heart, Lung, and Blood Institute (Program of Excellence in Nanotechnology (PEN) Award Contract HHSN268201000045C)en_US
dc.description.sponsorshipAlnylam Pharmaceuticals (Firm)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-EB000244–27)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 5-R01-CA132091–04)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-DE016516–03)en_US
dc.description.sponsorshipNational Institute for Biomedical Imaging and Bioengineering (U.S.) (Postdoctoral Fellowship 1F32EB017625)en_US
dc.description.sponsorshipUnited States. Dept. of Defense. Congressionally Directed Medical Research Programs (Postdoctoral Fellowship Award Grant W81XWH-13-1-0215)en_US
dc.description.sponsorshipJuvenile Diabetes Research Foundation International (Postdoctoral Fellowship Award)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/adhm.201400054en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleLipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivoen_US
dc.typeArticleen_US
dc.identifier.citationDong, Yizhou, Ahmed A. Eltoukhy, Christopher A. Alabi, Omar F. Khan, Omid Veiseh, J. Robert Dorkin, Sasilada Sirirungruang, et al. “Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo.” Adv. Healthcare Mater. 3, no. 9 (March 13, 2014): 1392–1397.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorDong, Yizhouen_US
dc.contributor.mitauthorEltoukhy, Ahmed A.en_US
dc.contributor.mitauthorAlabi, Christopher A.en_US
dc.contributor.mitauthorKhan, Omar F.en_US
dc.contributor.mitauthorVeiseh, Omiden_US
dc.contributor.mitauthorDorkin, J. Roberten_US
dc.contributor.mitauthorSirirungruang, Sasiladaen_US
dc.contributor.mitauthorYin, Haoen_US
dc.contributor.mitauthorTang, Benjamin C.en_US
dc.contributor.mitauthorPelet, Jeisa M.en_US
dc.contributor.mitauthorChen, Delaien_US
dc.contributor.mitauthorGu, Zhenen_US
dc.contributor.mitauthorXue, Yuanen_US
dc.contributor.mitauthorLanger, Roberten_US
dc.contributor.mitauthorAnderson, Daniel Griffithen_US
dc.relation.journalAdvanced Healthcare Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDong, Yizhou; Eltoukhy, Ahmed A.; Alabi, Christopher A.; Khan, Omar F.; Veiseh, Omid; Dorkin, J. Robert; Sirirungruang, Sasilada; Yin, Hao; Tang, Benjamin C.; Pelet, Jeisa M.; Chen, Delai; Gu, Zhen; Xue, Yuan; Langer, Robert; Anderson, Daniel G.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5786-0659
dc.identifier.orcidhttps://orcid.org/0000-0001-5629-4798
dc.identifier.orcidhttps://orcid.org/0000-0001-6898-3793
dc.identifier.orcidhttps://orcid.org/0000-0003-3811-2369
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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