Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer

Author(s)
Kim, Minkyu; Huang, Aaron; Kang, Jeon Woong; Suthiwangcharoen, Nisaraporn; Nagarajan, Ramanathan; ... Show more
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Abstract
A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.
Date issued
2014-02
URI
http://hdl.handle.net/1721.1/101212
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Laser Biomedical Research Center; Massachusetts Institute of Technology. Spectroscopy Laboratory
Journal
Chemical Communications
Publisher
Royal Society of Chemistry
Citation
Kim, Minkyu, Manos Gkikas, Aaron Huang, Jeon Woong Kang, Nisaraporn Suthiwangcharoen, Ramanathan Nagarajan, and Bradley D. Olsen. “Enhanced Activity and Stability of Organophosphorus Hydrolase via Interaction with an Amphiphilic Polymer.” Chem. Commun. 50, no. 40 (2014): 5345.
Version: Author's final manuscript
ISSN
1359-7345
1364-548X
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