Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer
Author(s)Kim, Minkyu; Huang, Aaron; Kang, Jeon Woong; Suthiwangcharoen, Nisaraporn; Nagarajan, Ramanathan; Gkikas, Emmanouil; Olsen, Bradley D; ... Show more Show less
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A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.
DepartmentMassachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Laser Biomedical Research Center; Massachusetts Institute of Technology. Spectroscopy Laboratory
Royal Society of Chemistry
Kim, Minkyu, Manos Gkikas, Aaron Huang, Jeon Woong Kang, Nisaraporn Suthiwangcharoen, Ramanathan Nagarajan, and Bradley D. Olsen. “Enhanced Activity and Stability of Organophosphorus Hydrolase via Interaction with an Amphiphilic Polymer.” Chem. Commun. 50, no. 40 (2014): 5345.
Author's final manuscript