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Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer

dc.contributor.authorKim, Minkyu
dc.contributor.authorHuang, Aaron
dc.contributor.authorKang, Jeon Woong
dc.contributor.authorSuthiwangcharoen, Nisaraporn
dc.contributor.authorNagarajan, Ramanathan
dc.contributor.authorGkikas, Emmanouil
dc.contributor.authorOlsen, Bradley D
dc.date.accessioned2016-02-18T20:53:30Z
dc.date.available2016-02-18T20:53:30Z
dc.date.issued2014-02
dc.date.submitted2013-10
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.urihttp://hdl.handle.net/1721.1/101212
dc.description.abstractA simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.en_US
dc.description.sponsorshipUnited States. Defense Threat Reduction Agency (Contract W911NF-07-D-0004)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (National Institute for Biomedical Imaging and Bioengineering (U.S.) P41EB015871-27)en_US
dc.description.sponsorshipMIT Skoltech Initiativeen_US
dc.language.isoen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c3cc47675hen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleEnhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymeren_US
dc.typeArticleen_US
dc.identifier.citationKim, Minkyu, Manos Gkikas, Aaron Huang, Jeon Woong Kang, Nisaraporn Suthiwangcharoen, Ramanathan Nagarajan, and Bradley D. Olsen. “Enhanced Activity and Stability of Organophosphorus Hydrolase via Interaction with an Amphiphilic Polymer.” Chem. Commun. 50, no. 40 (2014): 5345.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Laser Biomedical Research Centeren_US
dc.contributor.departmentMassachusetts Institute of Technology. Spectroscopy Laboratoryen_US
dc.contributor.mitauthorKim, Minkyuen_US
dc.contributor.mitauthorGkikas, Emmanouilen_US
dc.contributor.mitauthorHuang, Aaronen_US
dc.contributor.mitauthorKang, Jeon Woongen_US
dc.contributor.mitauthorOlsen, Bradley D.en_US
dc.relation.journalChemical Communicationsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKim, Minkyu; Gkikas, Manos; Huang, Aaron; Kang, Jeon Woong; Suthiwangcharoen, Nisaraporn; Nagarajan, Ramanathan; Olsen, Bradley D.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7272-7140
dc.identifier.orcidhttps://orcid.org/0000-0002-9476-6351
dc.identifier.orcidhttps://orcid.org/0000-0001-8334-5140
dc.identifier.orcidhttps://orcid.org/0000-0002-7356-5489
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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