Spatiotemporal Intracellular Nitric Oxide Signaling Captured Using Internalized, Near-Infrared Fluorescent Carbon Nanotube Nanosensors
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Fluorescent nanosensor probes have suffered from limited molecular recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathologies and physiological functions, using intracellular near-infrared fluorescent single-walled carbon nanotubes. The observed spatial-temporal NO signaling gradients clarify and refine the existing paradigm of NO signaling based on averaged local concentrations. This work enables the study of transient intracellular phenomena associated with signaling and therapeutics.
Date issued
2014-07Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical EngineeringJournal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Ulissi, Zachary W., Fatih Sen, Xun Gong, Selda Sen, Nicole Iverson, Ardemis A. Boghossian, Luiz C. Godoy, Gerald N. Wogan, Debabrata Mukhopadhyay, and Michael S. Strano. “Spatiotemporal Intracellular Nitric Oxide Signaling Captured Using Internalized, Near-Infrared Fluorescent Carbon Nanotube Nanosensors.” Nano Lett. 14, no. 8 (August 13, 2014): 4887–4894. © 2014 American Chemical Society
Version: Final published version
ISSN
1530-6984
1530-6992