Effect of sequence features on assembly of spider silk block copolymers
Author(s)
Tokareva, Olena S.; Lin, Shangchao; Jacobsen, Matthew M.; Huang, Wenwen; Rizzo, Daniel; Li, David; Simon, Marc; Staii, Cristian; Cebe, Peggy; Wong, Joyce Y.; Buehler, Markus J.; Kaplan, David L.; Buehler, Markus J.; ... Show more Show less![Thumbnail](/bitstream/handle/1721.1/101597/Buehler_Effect%20of.pdf.jpg?sequence=4&isAllowed=y)
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Bioengineered spider silk block copolymers were studied to understand the effect of protein chain length and sequence chemistry on the formation of secondary structure and materials assembly. Using a combination of in vitro protein design and assembly studies, we demonstrate that silk block copolymers possessing multiple repetitive units self-assemble into lamellar microstructures. Additionally, the study provides insights into the assembly behavior of spider silk block copolymers in concentrated salt solutions.
Date issued
2014-03Department
Massachusetts Institute of Technology. Department of Civil and Environmental EngineeringJournal
Journal of Structural Biology
Publisher
Elsevier
Citation
Tokareva, Olena S., Shangchao Lin, Matthew M. Jacobsen, Wenwen Huang, Daniel Rizzo, David Li, Marc Simon, et al. “Effect of Sequence Features on Assembly of Spider Silk Block Copolymers.” Journal of Structural Biology 186, no. 3 (June 2014): 412–419.
Version: Author's final manuscript
ISSN
10478477
1095-8657