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dc.contributor.authorIverson, Nicole M.
dc.contributor.authorAhn, Jiyoung
dc.contributor.authorNelson, Justin Theodore
dc.contributor.authorLandry, Markita P.
dc.contributor.authorKruss, Sebastian
dc.contributor.authorStrano, Michael S.
dc.contributor.authorBisker Raviv, Gili Hana
dc.contributor.authorDong, Juyao-Ivy
dc.contributor.authorPark, Hoyoung Daniel
dc.date.accessioned2016-03-17T01:20:47Z
dc.date.available2016-03-17T01:20:47Z
dc.date.issued2016-01
dc.date.submitted2015-01
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/1721.1/101732
dc.description.abstractCorona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-walled carbon nanotubes (SWCNT) and use it against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high selectivity. In response to fibrinogen binding, SWCNT fluorescence decreases by >80% at saturation. Sequential binding of the three fibrinogen nodules is suggested by selective fluorescence quenching by isolated sub-domains and validated by the quenching kinetics. The fibrinogen recognition also occurs in serum environment, at the clinically relevant fibrinogen concentrations in the human blood. These results open new avenues for synthetic, non-biological antibody analogues that recognize biological macromolecules, and hold great promise for medical and clinical applications.en_US
dc.description.sponsorshipJuvenile Diabetes Research Foundation Internationalen_US
dc.description.sponsorshipMIT-Technion Fellowshipen_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/ncomms10241en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNature Publishing Groupen_US
dc.titleProtein-targeted corona phase molecular recognitionen_US
dc.typeArticleen_US
dc.identifier.citationBisker, Gili, Juyao Dong, Hoyoung D. Park, Nicole M. Iverson, Jiyoung Ahn, Justin T. Nelson, Markita P. Landry, Sebastian Kruss, and Michael S. Strano. “Protein-Targeted Corona Phase Molecular Recognition.” Nat Comms 7 (January 8, 2016): 10241.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.mitauthorBisker Raviv, Gili Hanaen_US
dc.contributor.mitauthorDong, Juyao-Ivyen_US
dc.contributor.mitauthorPark, Hoyoung Danielen_US
dc.contributor.mitauthorAhn, Jiyoungen_US
dc.contributor.mitauthorNelson, Justin Theodoreen_US
dc.contributor.mitauthorStrano, Michael S.en_US
dc.relation.journalNature Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBisker, Gili; Dong, Juyao; Park, Hoyoung D.; Iverson, Nicole M.; Ahn, Jiyoung; Nelson, Justin T.; Landry, Markita P.; Kruss, Sebastian; Strano, Michael S.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9785-8297
dc.identifier.orcidhttps://orcid.org/0000-0002-0739-8352
dc.identifier.orcidhttps://orcid.org/0000-0003-2592-7956
dc.identifier.orcidhttps://orcid.org/0000-0001-6031-2338
dc.identifier.orcidhttps://orcid.org/0000-0003-2944-808X
dspace.mitauthor.errortrue
mit.licensePUBLISHER_CCen_US


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