Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers
Author(s)Tian, Fei; Min, Jouha; Kanka, Jiri; Li, Xiangzhi; Hammond, Paula T.; Du, Henry; ... Show more Show less
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A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 °C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Chemical Engineering
Optical Society of America
Tian, Fei, Jouha Min, Jiri Kanka, Xiangzhi Li, Paula T. Hammond, and Henry Du. “Lab-on-Fiber Optofluidic Platform for in Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers.” Optics Express 23, no. 15 (July 24, 2015): 20132.
Author's final manuscript