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Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers

Author(s)
Tian, Fei; Min, Jouha; Kanka, Jiri; Li, Xiangzhi; Du, Henry; Hammond, Paula T; ... Show more Show less
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Abstract
A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 °C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions.
Date issued
2015-07
URI
http://hdl.handle.net/1721.1/102405
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Optics Express
Publisher
Optical Society of America
Citation
Tian, Fei, Jouha Min, Jiri Kanka, Xiangzhi Li, Paula T. Hammond, and Henry Du. “Lab-on-Fiber Optofluidic Platform for in Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers.” Optics Express 23, no. 15 (July 24, 2015): 20132.
Version: Author's final manuscript
ISSN
1094-4087

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