Advanced Search

Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers

Research and Teaching Output of the MIT Community

Show simple item record Tian, Fei Min, Jouha Kanka, Jiri Li, Xiangzhi Hammond, Paula T. Du, Henry 2016-05-04T17:49:11Z 2016-05-04T17:49:11Z 2015-07 2015-07
dc.identifier.issn 1094-4087
dc.description.abstract A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 °C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions. en_US
dc.description.sponsorship National Science Foundation (U.S.) (Grant DMR-1206669) en_US
dc.description.sponsorship Czech Republic. Ministry of Education, Youth, and Sports (Grant LH 11038) en_US
dc.language.iso en_US
dc.publisher Optical Society of America en_US
dc.relation.isversionof en_US
dc.rights Creative Commons Attribution-Noncommercial-Share Alike en_US
dc.rights.uri en_US
dc.source Prof. Hammond via Erja Kajosalo en_US
dc.title Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers en_US
dc.type Article en_US
dc.identifier.citation Tian, Fei, Jouha Min, Jiri Kanka, Xiangzhi Li, Paula T. Hammond, and Henry Du. “Lab-on-Fiber Optofluidic Platform for in Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers.” Optics Express 23, no. 15 (July 24, 2015): 20132. en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Chemical Engineering en_US
dc.contributor.department David H. Koch Institute for Integrative Cancer Research at MIT en_US
dc.contributor.approver Hammond, Paula T. en_US
dc.contributor.mitauthor Min, Jouha en_US
dc.contributor.mitauthor Hammond, Paula T. en_US
dc.relation.journal Optics Express en_US
dc.identifier.mitlicense OPEN_ACCESS_POLICY en_US
dc.eprint.version Author's final manuscript en_US
dc.type.uri en_US
eprint.status en_US
dspace.orderedauthors Tian, Fei; Min, Jouha; Kanka, Jiri; Li, Xiangzhi; Hammond, Paula T.; Du, Henry en_US

Files in this item

Name Size Format
Downloadable Full Text - PDF

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution-Noncommercial-Share Alike Except where otherwise noted, this item's license is described as Creative Commons Attribution-Noncommercial-Share Alike
Open Access