Transcriptional Regulation and Its Misregulation in Disease

Author(s)
Lee, Tong Ihn; Young, Richard A.; Young, Richard A.
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Abstract
The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.
Description
Available in PMC 2014 March 14.
Date issued
2013-03
URI
http://hdl.handle.net/1721.1/103908
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Cell
Publisher
Elsevier
Citation
Lee, Tong Ihn, and Richard A. Young. "Transcriptional Regulation and Its Misregulation in Disease." Cell 152:6 (March 2013), pp. 1237-1251.
Version: Author's final manuscript
ISSN
00928674
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