| dc.contributor.author | Lee, Tong Ihn | |
| dc.contributor.author | Young, Richard A. | |
| dc.contributor.author | Young, Richard A. | |
| dc.date.accessioned | 2016-08-11T20:38:08Z | |
| dc.date.available | 2016-08-11T20:38:08Z | |
| dc.date.issued | 2013-03 | |
| dc.identifier.issn | 00928674 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/103908 | |
| dc.description | Available in PMC 2014 March 14. | en_US |
| dc.description.abstract | The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH grant CA146445) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH grant HG002668) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.cell.2013.02.014 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Transcriptional Regulation and Its Misregulation in Disease | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Lee, Tong Ihn, and Richard A. Young. "Transcriptional Regulation and Its Misregulation in Disease." Cell 152:6 (March 2013), pp. 1237-1251. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Whitehead Institute for Biomedical Research | en_US |
| dc.contributor.mitauthor | Young, Richard A. | en_US |
| dc.relation.journal | Cell | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Lee, Tong Ihn; Young, Richard A. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-8855-8647 | |
| mit.license | PUBLISHER_CC | en_US |
| mit.metadata.status | Complete | |
