Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP

Author(s)
Gao, Angela X.; Liao, Longyan; Johnson, Jeremiah A.
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Abstract
A panel of acid-labile bis-norbornene cross-linkers was synthesized and evaluated for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. An acetal-based cross-linker was identified that, when employed in conjunction with a poly(ethylene glycol) (PEG) macromonomer, provided highly controlled BASP formation reactions. A combination of this new cross-linker with a novel doxorubicin (DOX)-branch-PEG macromonomer provided BASPs that simultaneously degrade and release cytotoxic DOX in vitro.
Date issued
2014-08
URI
http://hdl.handle.net/1721.1/104965
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
ACS Macro Letters
Publisher
American Chemical Society (ACS)
Citation
Gao, Angela X., Longyan Liao, and Jeremiah A. Johnson. “Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP.” ACS Macro Letters 3, no. 9 (September 16, 2014): 854–857. © 2014 American Chemical Society.
Version: Final published version
ISSN
2161-1653
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