| dc.contributor.author | Gao, Angela X. | |
| dc.contributor.author | Liao, Longyan | |
| dc.contributor.author | Johnson, Jeremiah A. | |
| dc.date.accessioned | 2016-10-24T20:51:37Z | |
| dc.date.available | 2016-10-24T20:51:37Z | |
| dc.date.issued | 2014-08 | |
| dc.date.submitted | 2014-07 | |
| dc.identifier.issn | 2161-1653 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/104965 | |
| dc.description.abstract | A panel of acid-labile bis-norbornene cross-linkers was synthesized and evaluated for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. An acetal-based cross-linker was identified that, when employed in conjunction with a poly(ethylene glycol) (PEG) macromonomer, provided highly controlled BASP formation reactions. A combination of this new cross-linker with a novel doxorubicin (DOX)-branch-PEG macromonomer provided BASPs that simultaneously degrade and release cytotoxic DOX in vitro. | en_US |
| dc.description.sponsorship | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.description.sponsorship | National Institute for Biomedical Imaging and Bioengineering (U.S.) (NIBIB 1R21EB018529-01A1) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/mz5004097 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | ACS | en_US |
| dc.title | Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Gao, Angela X., Longyan Liao, and Jeremiah A. Johnson. “Synthesis of Acid-Labile PEG and PEG-Doxorubicin-Conjugate Nanoparticles via Brush-First ROMP.” ACS Macro Letters 3, no. 9 (September 16, 2014): 854–857. © 2014 American Chemical Society. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Gao, Angela X. | |
| dc.contributor.mitauthor | Liao, Longyan | |
| dc.contributor.mitauthor | Johnson, Jeremiah A. | |
| dc.relation.journal | ACS Macro Letters | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Gao, Angela X.; Liao, Longyan; Johnson, Jeremiah A. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-9157-6491 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
