Predicting Knee Osteoarthritis
Author(s)
Zhang, Lihai; Gardiner, Bruce S.; Woodhouse, Francis G.; Besier, Thor F.; Lloyd, David G.; Smith, David W.; Grodzinsky, Alan J; ... Show more Show less
Download10439_2015_Article_1393.pdf (2.787Mb)
PUBLISHER_CC
Publisher with Creative Commons License
Creative Commons Attribution
Terms of use
Metadata
Show full item recordAbstract
Treatment options for osteoarthritis (OA) beyond pain relief or total knee replacement are very limited. Because of this, attention has shifted to identifying which factors increase the risk of OA in vulnerable populations in order to be able to give recommendations to delay disease onset or to slow disease progression. The gold standard is then to use principles of risk management, first to provide subject-specific estimates of risk and then to find ways of reducing that risk. Population studies of OA risk based on statistical associations do not provide such individually tailored information. Here we argue that mechanistic models of cartilage tissue maintenance and damage coupled to statistical models incorporating model uncertainty, united within the framework of structural reliability analysis, provide an avenue for bridging the disciplines of epidemiology, cell biology, genetics and biomechanics. Such models promise subject-specific OA risk assessment and personalized strategies for mitigating or even avoiding OA. We illustrate the proposed approach with a simple model of cartilage extracellular matrix synthesis and loss regulated by daily physical activity.
Date issued
2015-07Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer ScienceJournal
Annals of Biomedical Engineering
Publisher
Springer US
Citation
Gardiner, Bruce S. et al. “Predicting Knee Osteoarthritis.” Annals of Biomedical Engineering 44.1 (2016): 222–233.
Version: Final published version
ISSN
0090-6964
1573-9686