Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo
Author(s)Abutbul-Ionita, Inbal; Danino, Dganit; DeRosa, Frank; Heartlein, Michael; Dong, Yizhou; Dorkin, Joseph Robert; Wang, Weiheng; Webber, Matthew; Tang, Benjamin C.; Yang, Jung H; Langer, Robert S; Anderson, Daniel Griffith; Chang, Philip H.; ... Show more Show less
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Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII and mRNA-encoding erythropoietin (EPO) in mice. Importantly, these nanoparticles were well-tolerated at their effective dose based on analysis of tissue histology, systemic cytokine levels, and liver enzyme chemistry. The polymer brush nanoparticles reported here are promising for therapeutic applications.
DepartmentMassachusetts Institute of Technology. Institute for Medical Engineering & Science; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
American Chemical Society (ACS)
Dong, Yizhou et al. “Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo.” Nano Letters 16.2 (2016): 842–848.
Author's final manuscript