Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Author(s)
Abutbul-Ionita, Inbal; Danino, Dganit; DeRosa, Frank; Heartlein, Michael; Dong, Yizhou; ... Show more
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Abstract
Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII and mRNA-encoding erythropoietin (EPO) in mice. Importantly, these nanoparticles were well-tolerated at their effective dose based on analysis of tissue histology, systemic cytokine levels, and liver enzyme chemistry. The polymer brush nanoparticles reported here are promising for therapeutic applications.
Date issued
2014-01
URI
http://hdl.handle.net/1721.1/107111
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Dong, Yizhou et al. “Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo.” Nano Letters 16.2 (2016): 842–848.
Version: Author's final manuscript
ISSN
1530-6984
1530-6992
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