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Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

dc.contributor.authorAbutbul-Ionita, Inbal
dc.contributor.authorDanino, Dganit
dc.contributor.authorDeRosa, Frank
dc.contributor.authorHeartlein, Michael
dc.contributor.authorDong, Yizhou
dc.contributor.authorDorkin, Joseph Robert
dc.contributor.authorWang, Weiheng
dc.contributor.authorWebber, Matthew
dc.contributor.authorTang, Benjamin C.
dc.contributor.authorYang, Jung H
dc.contributor.authorLanger, Robert S
dc.contributor.authorAnderson, Daniel Griffith
dc.contributor.authorChang, Philip H.
dc.date.accessioned2017-02-23T14:38:43Z
dc.date.available2017-02-23T14:38:43Z
dc.date.issued2014-01
dc.date.submitted2015-06
dc.identifier.issn1530-6984
dc.identifier.issn1530-6992
dc.identifier.urihttp://hdl.handle.net/1721.1/107111
dc.description.abstractSafe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII and mRNA-encoding erythropoietin (EPO) in mice. Importantly, these nanoparticles were well-tolerated at their effective dose based on analysis of tissue histology, systemic cytokine levels, and liver enzyme chemistry. The polymer brush nanoparticles reported here are promising for therapeutic applications.en_US
dc.description.sponsorshipMIT-Harvard Center of Cancer Nanotechnology Excellence (Grant U54-CA151884)en_US
dc.description.sponsorshipNational Heart, Lung, and Blood Institute (Contract HHSN268201000045C)en_US
dc.description.sponsorshipShire Pharmaceuticalsen_US
dc.description.sponsorshipAlnylam Pharmaceuticals (Firm)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grants R01-EB000244-27, 5- R01-CA132091-04, and R01-DE016516-03)en_US
dc.description.sponsorshipNational Institute for Biomedical Imaging and Bioengineering (U.S.) (Postdoctoral Fellowship 1F32EB017625)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acs.nanolett.5b02428en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titlePoly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivoen_US
dc.typeArticleen_US
dc.identifier.citationDong, Yizhou et al. “Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo.” Nano Letters 16.2 (2016): 842–848.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorDong, Yizhou
dc.contributor.mitauthorDorkin, Joseph Robert
dc.contributor.mitauthorWang, Weiheng
dc.contributor.mitauthorChang, Philip
dc.contributor.mitauthorWebber, Matthew
dc.contributor.mitauthorTang, Benjamin C.
dc.contributor.mitauthorYang, Jung H
dc.contributor.mitauthorLanger, Robert S
dc.contributor.mitauthorAnderson, Daniel Griffith
dc.relation.journalNano Lettersen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDong, Yizhou; Dorkin, J. Robert; Wang, Weiheng; Chang, Philip H.; Webber, Matthew J.; Tang, Benjamin C.; Yang, Junghoon; Abutbul-Ionita, Inbal; Danino, Dganit; DeRosa, Frank; Heartlein, Michael; Langer, Robert; Anderson, Daniel G.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5786-0659
dc.identifier.orcidhttps://orcid.org/0000-0003-3298-6022
dc.identifier.orcidhttps://orcid.org/0000-0003-0624-3532
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
dc.identifier.orcidhttps://orcid.org/0000-0001-5629-4798
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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