Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery
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Synthetic regulatory circuits encoded in RNA rather than DNA could provide a means to control cell behavior while avoiding potentially harmful genomic integration in therapeutic applications. We create post-transcriptional circuits using RNA-binding proteins, which can be wired in a plug-and-play fashion to create networks of higher complexity. We show that the circuits function in mammalian cells when encoded in modified mRNA or self-replicating RNA.
Date issued
2015-08Department
Massachusetts Institute of Technology. Department of Biological EngineeringJournal
Nature Biotechnology
Publisher
Nature Publishing Group
Citation
Wroblewska, Liliana et al. “Mammalian Synthetic Circuits with RNA Binding Proteins for RNA-Only Delivery.” Nature Biotechnology 33.8 (2015): 839–841.
Version: Author's final manuscript
ISSN
1087-0156
1546-1696