| dc.contributor.author | Endo, Kei | |
| dc.contributor.author | Saito, Hirohide | |
| dc.contributor.author | Wroblewska, Liliana | |
| dc.contributor.author | Kitada, Tasuku | |
| dc.contributor.author | Siciliano, Velia | |
| dc.contributor.author | DiAndreth, Breanna Elizabeth | |
| dc.contributor.author | Weiss, Ron | |
| dc.date.accessioned | 2017-02-23T14:54:14Z | |
| dc.date.available | 2017-02-23T14:54:14Z | |
| dc.date.issued | 2015-08 | |
| dc.date.submitted | 2015-04 | |
| dc.identifier.issn | 1087-0156 | |
| dc.identifier.issn | 1546-1696 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/107113 | |
| dc.description.abstract | Synthetic regulatory circuits encoded in RNA rather than DNA could provide a means to control cell behavior while avoiding potentially harmful genomic integration in therapeutic applications. We create post-transcriptional circuits using RNA-binding proteins, which can be wired in a plug-and-play fashion to create networks of higher complexity. We show that the circuits function in mammalian cells when encoded in modified mRNA or self-replicating RNA. | en_US |
| dc.description.sponsorship | United States. Defense Advanced Research Projects Agency (Grant DARPA-BAA-11-23) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grants P50-GM098792 and 5-R01-CA155320-03) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.). Graduate Research Fellowship Program (Grant 1122374) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Nature Publishing Group | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1038/nbt.3301 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Wroblewska, Liliana et al. “Mammalian Synthetic Circuits with RNA Binding Proteins for RNA-Only Delivery.” Nature Biotechnology 33.8 (2015): 839–841. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.mitauthor | Wroblewska, Liliana | |
| dc.contributor.mitauthor | Kitada, Tasuku | |
| dc.contributor.mitauthor | Siciliano, Velia | |
| dc.contributor.mitauthor | DiAndreth, Breanna Elizabeth | |
| dc.contributor.mitauthor | Weiss, Ron | |
| dc.relation.journal | Nature Biotechnology | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Wroblewska, Liliana; Kitada, Tasuku; Endo, Kei; Siciliano, Velia; Stillo, Breanna; Saito, Hirohide; Weiss, Ron | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-2265-3363 | |
| dc.identifier.orcid | https://orcid.org/0000-0001-7734-9153 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-0302-6834 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-0396-2443 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
