Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties

Author(s)
Yesilyurt, Volkan; Webber, Matthew; Appel, Eric; Godwin, Colin; Langer, Robert S; ... Show more
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Abstract
Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.
Date issued
2015-11
URI
http://hdl.handle.net/1721.1/107195
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Materials
Publisher
Wiley Blackwell
Citation
Yesilyurt, Volkan et al. “Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.” Advanced Materials 28.1 (2016): 86–91.
Version: Original manuscript
ISSN
0935-9648
1521-4095
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