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Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties

dc.contributor.authorYesilyurt, Volkan
dc.contributor.authorWebber, Matthew
dc.contributor.authorAppel, Eric
dc.contributor.authorGodwin, Colin
dc.contributor.authorLanger, Robert S
dc.contributor.authorAnderson, Daniel Griffith
dc.date.accessioned2017-03-06T17:28:44Z
dc.date.available2017-03-06T17:28:44Z
dc.date.issued2015-11
dc.date.submitted2015-09
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.urihttp://hdl.handle.net/1721.1/107195
dc.description.abstractDynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.en_US
dc.description.sponsorshipLeona M. and Harry B. Helmsley Charitable Trust (Award 2014PG-T1D002)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32DK101335)en_US
dc.description.sponsorshipWellcome Trust-MIT Postdoctoral Fellowshipen_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/adma.201502902en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleInjectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Propertiesen_US
dc.typeArticleen_US
dc.identifier.citationYesilyurt, Volkan et al. “Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.” Advanced Materials 28.1 (2016): 86–91.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorYesilyurt, Volkan
dc.contributor.mitauthorWebber, Matthew
dc.contributor.mitauthorAppel, Eric
dc.contributor.mitauthorGodwin, Colin
dc.contributor.mitauthorLanger, Robert S
dc.contributor.mitauthorAnderson, Daniel Griffith
dc.relation.journalAdvanced Materialsen_US
dc.eprint.versionOriginal manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsYesilyurt, Volkan; Webber, Matthew J.; Appel, Eric A.; Godwin, Colin; Langer, Robert; Anderson, Daniel G.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9944-3562
dc.identifier.orcidhttps://orcid.org/0000-0003-0624-3532
dc.identifier.orcidhttps://orcid.org/0000-0002-2301-7126
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
dc.identifier.orcidhttps://orcid.org/0000-0001-5629-4798
mit.licenseOPEN_ACCESS_POLICYen_US


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