Neuroprotection and acidosis induced by cortical spreading depression
Author(s)
Chan, Suk-tak; Kwong, Kenneth K![Thumbnail](/bitstream/handle/1721.1/107754/Kwong-2016-Neuroprotection%20and%20acidosis%20induce.pdf.jpg?sequence=4&isAllowed=y)
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We read with interest the article “Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5” published in Neuropsychiatr Dis Treat by Viggiano et al.1 The authors showed that cerebral spreading depression (CSD) triggered uncoupling protein-5 (UCP-5),1 which had been reported to exert a long-term effect upon neuron protection.2 The result is another piece in CSD literature on modifying gene expressions to provide neuroprotection to subsequent ischemic episodes.3,4
Date issued
2016-12Department
Harvard University--MIT Division of Health Sciences and TechnologyJournal
Neuropsychiatric Disease and Treatment
Publisher
Dove Medical Press
Citation
Kwong, Kenneth, and Suk-tak Chan. “Neuroprotection and Acidosis Induced by Cortical Spreading Depression.” Neuropsychiatric Disease and Treatment Volume 12 (2016): 3191–3194.
Version: Final published version
ISSN
1178-2021