Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications
Author(s)Liu, Haipeng; Irvine, Darrell J
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Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure–function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Materials Science and Engineering; Ragon Institute of MGH, MIT and Harvard
American Chemical Society (ACS)
Liu, Haipeng, and Darrell J. Irvine. “Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications.” Bioconjugate Chemistry 26, no. 5 (May 20, 2015): 791–801. © 2015 American Chemical Society
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