Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications

Author(s)
Liu, Haipeng; Irvine, Darrell J
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Abstract
Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure–function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies.
Date issued
2015-05
URI
http://hdl.handle.net/1721.1/108144
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Materials Science and Engineering; Ragon Institute of MGH, MIT and Harvard; Koch Institute for Integrative Cancer Research at MIT
Journal
Bioconjugate Chemistry
Publisher
American Chemical Society (ACS)
Citation
Liu, Haipeng, and Darrell J. Irvine. “Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications.” Bioconjugate Chemistry 26, no. 5 (May 20, 2015): 791–801. © 2015 American Chemical Society
Version: Author's final manuscript
ISSN
1043-1802
1520-4812
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